Unconventional synthesis of nitrogenated heterocycles with potencial bioactive properties

Introduction In recent years, a new approach called “Green Chemistry” emerged in the field of organic chemistry, to prevent or minimize contamination from the laboratory bench up to industrial production. It purpose is to avoid residue formation, saving time and costs. One of the strategies proposed for the existing products involves designing alternative synthesis steps that do not use toxic substrates or solvents, nor do they generate toxic by products. Also, new synthesis methodologies successfully applied with unconventional power sources can be used, such as infrared and microwave (MW) radiations and ultrasound, among others. The development of combinatorial chemistry has accelerated the discovery process for new active compounds and raised interest in the development of solidphase synthesis (SPS) methodologies for organic molecules. All these have widened the horizons for searching for new potential drug candidates. In this paper, we describe the synthesis of nitrogenated heterocyclic compounds with potential bioactive properties by MW-assisted organic synthesis procedures in the absence of solvents and SPS.